kidney stones, health

The Precursors to Illness: Do Genes Play a Role in Developing Kidney Stones?


With the health condition known as ‘kidney stones’ affecting over 1 million Americans every single year, as well as being known as one of the most painful and uncomfortable, it’s no wonder so many people are looking for how the stones are formed, and how the risk of developing them can be reduced.

However, more and more people are asking whether the risk of stones is a genetic condition, and if someone else in your family had them, does that mean the risk can be passed down to you? Today, we’re going to explore the ins and outs of this subject, so you have everything you need to know about you and kidney stones.

How Are Kidney Stones Formed?

A lot of research has been taking place into this subject, mainly on mice whose bodies and internal organs work in a very similar way to humans.  As it turns out, kidney stones form when the urine in an individual becomes too concentrated, at least far greater than normal.

This, in turn, causes the urine to crystallize and the particles start to stick and hold together. Of course, this over time causes them the formations to become stone-like, which is then referred to as a kidney stone.

 What Causes Kidney Stones to Form?

 During the same research, it was discovered that diet plays a major role in the formation of kidney stones. But there are many variables to consider. For example, not drinking enough water can cause them to form and increases the overall risk.

Other dietary problems like consuming too much salt can be a cause because this substance assists in the binding of calcium, which comes together to create the stones. Of course, there are many lifestyle considerations to think about as well, whether that’s smoking and fitness levels, and how much alcohol is consumed and other kinds of choices.

So, Genes Aren’t to Blame?

Well, they do play a certain role. During an ongoing study back in 2012, it was discovered that there is a common gene variation known as ‘Claudin-14’. This gene variation has been linked with a dramatic increase in the risk of developing kidney stones; sometimes as much as 65%.

A later study found that this gene is not commonly active in the kidney since it’s suppressed by RNA, a sister molecule to DNA, meaning that minerals like calcium and salt can be passed through the cell wall where they can be used by the body.

However, with the dietary concerns we spoke about above, the gene can become activated which then actively suppresses the flow of calcium and other minerals; which then build up and form very painful kidneys, which will need to be removed or treated using remedies that worked for Roger Baxter.

Of course, if you have a genetic problem that relates to this area of your diet, or a condition that weakens your RNA, this is going to activate the Claudin-14 gene which can lead to kidney stones.


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